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Tumor growth modeling based on medical images of electroporation-treated patients

STSM by Tadeja Forjanič, PhD Student

Period of mission: from 01/12/2014 to 10/12/2014

Home institution: University of Ljubljana, Faculty of Electrical Engineering, Ljubljana, Slovenia

Host institution: INRIA Bordeaux - Sud-Ouest Research Center, Talence, France

Tumor growth modeling is a promising approach for evaluation of response to electroporation based treatments. The aim of my STSM was to explore the possibilities of modeling the growth and inhibition of colorectal liver metastases treated with electrochemotherapy (ECT). Since it was not possible to accurately measure lesion dimensions on available medical images, the time behavior could not be obtained. However, radiooncologist made an interesting observation that in all cases showing the partial response to the treatment, metastases were located in close proximity to big blood vessels. According to his opinion major hepatic vessels can affect and degrade the treatment. This requires further investigation of underlying processes in order to improve the treatment efficacy. Additionally, we were working on modeling the tumor response using the data of tumor growth in mice treated with ECT. We have developed a two-compartment model based on ordinary differential equations that describes the tumor volume changes with time after the treatment. First compartment includes the cells that are not affected by the treatment, so their total volume increases according to the Gompertz law, whereas cells from second compartment eventually die due to damages induced by the treatment. Since described model showed a good approximation to our experimental data, it can be used to study underlying mechanisms in order to get a more complete picture of tumor responses to ECT.

Poster presentation(s) originating from this mission

Event 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies
Location Portorož/Slovenia
Period

06/09 - 10/09/2015

Authors Tadeja Forjanič, Damijan Miklavčič
Title Modeling of tumor growth inhibition in mice following electrochemotherapy

 


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