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Individual electroporation treatment planning for rats brain

STSM by Shirley Sharabi, PhD Student

Period of mission: from 12/04/2015 to 25/04/2015

Home institution: Tel-Aviv University, Sackler Faculty of Medicine, Tel-Aviv / Sheba Medical Center, The Advanced Technology Center, Ramat-Gan, Israel

Host institution: University of Ljubljana, Faculty of Electrical Engineering, Ljubljana, Slovenia

The overall goal of our research is developing individual treatment planning for brain tumors using local point-source electroporation combined with systemic chemotherapy. The goal of the mission was to develop a mathematical model describing the effect of electrical fields and number of treatment pulses on treatment outcome, including irreversible tissue damage and blood-brain barrier (BBB) disruption which enables efficient drug delivery. It was previously suggested that the Peleg-Fermi statistical model can describe cells survival probability after electroporation. During the STSM we used experimental data obtained from Magnetic Resonance images of naïve rats treated by electroporation with a single intracranial electrode using different number of pulses and fitted the results to the Peleg-Fermi model. The model computes the ratio of surviving cells after electroporation depending on of the applied electric field and number of pulses.

The coeeficients of the equation were computed by optimization methods and the results of the model were compared to experimental data on irreversible electroporation (IRE) the rats' brain. The same model was then adopted to describe the BBB disruption in the brain tissue and new coeeficients were computed from the model.

Electrical field thresholds were calculated for IRE and BBB disruption for different number of pulses. These thresholds can be used for efficient treatment planning for brain tumors, where irreversible electroporation is used for the destruction of the tumor mass and the BBB disruption is used in combination with chemotherapy to assist in drug delivery to the tumor.

Publication(s) originating from this mission

Journal Radiology and Oncology
Impact Factor (according to ISI Thomson) 1,912
Authors Shirley Sharabi,  Bor Kos, David Last, David Guez, Dianne Daniels, Sagi Harnof, Yael Mardor, Damijan Miklavcic
Title A statistical model describing combined irreversible electroporation and electroporation-induced blood-brain barrier disruption
Year 2016
Issue 50(1)
Pages 28-38
Status Published

 


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