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In vivo behaviour of novel electrode designs

STSM by Quim Castellvi, PhD Student

Period of mission: from 03/03/2013 to 23/03/2013

Home institution: Universitat Pompeu Fabra, Barcelona, Spain

Host institution: 8203 CNRS, Institut Gustave Roussy, Villejuif, France

Precise control over the electric field magnitude that develops in tissues is crucial for electroporation therapies and thus optimum electric field distributions are sought for. With such objective in mind, numerical models and tools are being developed for helping in the process of specifying the location of the electrodes and the voltages to be applied between those electrodes. Sophisticated treatment planning tools are being developed for indicating where the electrodes must be placed. Therefore, deployment accuracy and mechanical stability of the electrodes will be key features for optimum treatment, particularly in the case of internal organs. Without mechanical stability – which is particularly compromised due to involuntary movements caused by the electric pulses required for electroporation – fine pre-treatment planning employing advanced numerical methods will be of little use. The aim of the STSM was to study the mechanical performance of novel electrode setups in in vivo environments. Specifically, the novel electrode arrays were tried in rat liver and skeletal muscle under ultrasound imaging guidance. Tissue samples were collected for posterior histological analysis in which damage caused by electrode insertion, by electroporation treatment and by electrode extraction will be assessed. In addition, extraction forces were registered with a custom-developed force measurement system. Interestingly, it turns out that extraction forces are consistently higher after performing electroporation, thus revealing some sort of modification of mechanical properties of tissue or of the mechanical properties of the interface between the tissue and the electrode. We are now performing further experiments for elucidating the cause, or causes, of such increase in extraction force.

This report is also featured in the July 2013 newsletter available here.

Oral presentation(s) originating from this mission

Event 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies
Location Portorož/Slovenia
Period 06/09 - 10/09/2015
Authors Quim Castellví, Patricia Sánchez-Velázquez, Alberto Villanueva, Enrique Berjano, Fernando Burdío and Antoni Ivorra
Title Sudden Death of Mice after Irreversible Electroporation of a Large Portion of the Liver: Probable Role of Hyperkalemia

 


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