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Electromagnetic modeling of biological cells subjected to impulsive electrical fields VS experimental data: the role of the membrane excitability

STSM by Patrizia Lamberti, Researcher

Period of mission: from 02/01/2014 to 11/01/2014

Home institution: DIEM - University of Salerno, Fisciano (SA), Italy

Host institution: Laboratory of Biocybernetics - University of Ljubjana, Ljubljana, Slovenia

"A model is useful? Model is nothing without experiments but model can be used to understand and address experimental results". With this idea in my mind, I proposed myself for a STSM inside this Cost action. The STSM had the scope to exchange experiences concerning the pulsed electric field (PEF) treatment of excitable cell. In particular the hosting laboratory (i.e. Ljubljana’s Laboratory of Biocybernetics, under the supervision of prof. Damijan Miklavčič – "GURU") is performing experimental test on the electrical behaviour of Normal Rat Kidney cell with respect to PEF whereas Dr. Patrizia Lamberti (i.e. me, small and remote Italian researcher) is developing a circuital model of this particular excitable cell. During the STSM the model was improved in order to describe the electromagnetic cell membrane behaviour if the electroporation is taken into account together with the reproduction of the membrane excitability. The obtained ITMV and N behaviours suggest that at the “onset” of the electroporation phenomenon, membrane excitability is not so influent. Moreover it seems that the excitability reduce the pore creation rate and its influence increases if successive pulses are considered. "The experiments represent the reality that model tries to reproduce but the experiments can be affect by neglected sources of noise shadowing the principal. A model is capable to detect the 'main phenomenon' influencing the real behaviour of biological matter by repetition of simplest and cheapest numerical procedures with respect to experimental ones: a model can be useful!". Thanks to the exchange of experiences with the beautiful researchers involved with the Laboratory of Biocybernetics of University of Ljubljana, I restart my research activity at home institution after this STSM with this new idea in my mind!

Poster presentation(s) originating from this mission

Event 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies
Location Portorož/Slovenia
Period

06/09 - 10/09/2015

Authors Patrizia Lamberti, Stefania Romeo, Maria Rosaria Scarfì, Vincenzo Tucci, Luigi Zeni
Title Numerical analysis of split dose protocols for nsPEFelectroporation

 


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