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Mechanical phenomena in transdermal drug delivery with electroporation and other physical methods

STSM by Nataša Pavšelj, Researcher

Period of mission: from 05/10/2014 to 08/11/2014

Home institution: University of Ljubljana, Faculty of Electrical Engineering, Ljubljana, Slovenia

Host institution: University of Canterbury, Department of Mechanical Engineering, Christchurch, New Zealand

In collaboration with Dr. Sid Becker from the Host institution, we have recently added new knowledge into the field of transdermal drug delivery with electroporation, in which we have shown that more pulses do not necessarily mean more transdermal delivery and that the order of the types of pulses administered must also be considered (Zorec at al., International Journal of Pharmaceutics, 2013). We experimented with different combinations of short high-voltage (HV) and long low-voltage (LV) pulses, focusing primarily on the order of pulses. We anticipated that a combination of HV (creation of small aqueous pathways), followed by LV pulses (expansion into bigger local transport regions - LTRs) will work in synergy and will result in better molecular delivery. However, we have shown that the total transport of solute was decreased when LV pulses were preceded by HV pulses. During the STSM we explored this phenomenon further, focusing on analytical description of LTR expansion depending on the initial conditions of the skin, i.e. the size and the density of the preexisting small aqueous pathways. We described the thermodynamics underlying the LTR evolution with an analytical model that shows directly how the heating time required to initiate LTR evolution is dependent upon the pre-existing stratum corneum pathway size and density. The pore size and density strongly influence the pulsing time required to attain sufficient resistive heating to reach lipid phase transition temperatures required for LTR expansion, which agrees with our experimental data.

Publication(s) originating from this mission

Journal Journal of Biomechanical Engineering
Impact Factor (according to ISI Thomson) 1,780
Authors Nataša Pavšelj, Barbara Zorec, Damijan Miklavčič, Sid Becker
Title Experimental Factors to be Consideredin Electroporation-Mediated Transdermal Diffusion Experiments
Year 2015
Issue ?
Pages ?
Status Accepted for publication - to be updated 

Oral presentation(s) originating from this mission

Event 3rd International Conference on Computational Methods for Thermal Problems (ThermaComp2014)
Location Lake Bled/Slovenia
Period 02/06 - 04/06/2014
Authors Barbara Zorec, ??? (to be updated)
Title Computational modeling of skin electroporation: reconciliation between experimental observations and anticipated physics

 

Event 23rd International Symposium on Transport Phenomena
Location Auckland/New Zeeland
Period 19/11 - 22/11/2012
Authors Sid Becker, Barbara Zorec, Nataša Pavšelj, Damijan Miklavčič
Title Transport Modeling of Skin Electroporation and the Thermal Behavior of the Stratum Corneum

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