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Experimental assessment of the performance of an antenna prototype to apply nsPEF

STSM by Caterina Merla, Early-Stage Researcher

Period of mission: from 30/04/2015 to 23/05/2015

Home institution: Italian National Agency for New Technology, Energy, Sustainable Economic Development, Radiation Biology and Human Health Unit, Rome, Italy

Host institution: Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, US

This STSM focuses on accurate experimental characterization of an EM exposure setup developed (theoretical design, numerical simulations) at the ENEA, Rome, Italy. The setup, built under the scope of a common Italian-American research effort involving the study of nanosecond pulsed electric fields and cancer-related mechanisms, allows the exposure of newborn mice to extremely short (5 ns) and intense (MV/m) electric pulses. Two device prototypes were completely characterized in frequency and time domains. Antenna performance tests, loaded and unloaded with a suitable dielectric, consisting of frequency domain measurements up to 3 GHz, were carried out using a VNA. Then, a high-voltage generator was used to deliver single or multiple 6 ns pulses. A tap-off was used to acquire on an oscilloscope both the input and reflected signals from the device. The electric fields emitted at different distances and positions over the antenna patch (loaded and unloaded) were measured using a D-dot sensor. We obtained a total transmitted voltage into the antenna of nearly 40% of the input voltage. Although the data show rather large reflections; the pulse rise/fall times are not degraded. Good measurement repeatability was obtained. We see now that we need to improve the performance at lower frequencies. However, the dielectric matching slab for holding biological samples increases the amplitude of the radiated electric field.

Despite limitations, the present setup can be used to expose biological targets to shorter pulses, even down to the picosecond regime.

Publication(s) originating from this mission

Journal Medical & Biological Engineering & Computing
Impact Factor (according to ISI Thomson) 1,700
Authors Caterina Merla, Francesca Apollonio, Alessandra Paffi, Carmela Marino, P. Thomas Vernier, M. Liberti
Title Monopole patch antenna for in vivo exposure to nanosecond pulsed electric fields
Year 2015
Issue ?
Pages ?
Status Submitted - to be updated

Conference abstract(s) originating from this mission

Publication IFMBE Proceedings of the 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies
Publisher Tomaz J, Kramar P (ed), 1st edn. Springer-Verlag, Singapur
Authors Caterina Merla, Alessandra Paffi, Priscilla Monaco, Teresa Calderaro, Francesca Apollonio, Carmela Marino, P. Thomas Vernier, Micaela Liberti
Title Design of an applicator for nsPEF exposure of newborn mice
Year 2015
Issue 53
Pages 228-231
Status Published

Oral presentation(s) originating from this mission

Event 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies
Location Portorož/Slovenia
Period 06/09 - 10/09/2015
Authors Paolo Marracino, Micaela Liberti, Francesca Apollonio and Andrea Amadei
Title nsPEfs induce irreversible denaturation of sperm whale myoglobin: a thermodynamics analysis

Poster presentation(s) originating from this mission

Event 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies
Location Portorož/Slovenia
Period

06/09 - 10/09/2015

Authors Caterina Merla, Alessandra Paffi, Priscilla Monaco, Teresa Calderaro, Francesca Apollonio, Carmela Marino, P. Thomas Vernier, Micaela Liberti
Title Design of an applicator for nsPEF exposure of newborn mice

 


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