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Improving treatment planning for IRE with advanced numerical models

STSM by Bor Kos, Early-Stage Researcher

Period of mission: from 26/04/2014 to 11/05/2014

Home institution: University of Ljubljana, Ljubljana, Slovenia

Host institution: Virginia Tech, Blacksburg, Virgina, USA

Non-thermal irreversible electroporation for the treatment of brain cancer is promising avenue of research according to preliminary studies on veterinary patients. The goal of the STSM was to finalize a user-friendly interface and computational back-end for treatment planning of non-thermal irreversible electroporation of canine brain tumors. We analyzed a group of 5 canine patients, which were treated with non-thermal irreversible electroporation. The patients presented with spontaneous brain tumors of various histologies. During the STSM we implemented a statistical model for cell death based on in-vitro studies in a computational finite-element method model (built in COMSOL Multiphysics v4.3b), and correlated the model predictions with actual treatment outcomes. Additionally, we implemented thermal simulations into the model, which initially only took electric fields into account. The new results for cell viability after electroporation treatment (statistical model) are very promising, since they show characteristics, which are very much in line with experimental results obtained in vivo. This presents one of the first studies, which will be able to directly correlate in-vivo results treatment efficacy in with computed in-situ electric fields, with electrode positions exactly known from intra-operative CT scans and/or stereotactic frame use.

Oral presentation(s) originating from this mission

Event 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies
Location Portorož/Slovenia
Period 06/09 - 10/09/2015
Authors Garcia, Paulo A., Kos, Bor, Pavliha, Denis, Rossmeisl, John H., Miklavčič, Damijan, Davalos, Rafael V.
Title A comparison between deterministic and statistical treatment planning in irreversible electroporation of spontaneous glioma

 


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