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Improvement of IRE models for treatment planning based on clinical data in human patients

STSM by Bor Kos, Early-Stage Researcher

Period of mission: from 15/12/2014 to 19/12/2014

Home institution: University of Ljubljana, Faculty of Electrical Engineering, Ljubljana, Slovenia

Host institution: Dept of Diagnostic and Interventional Radiology, Universitätsklinikum Leipzig AöR, Leipzig, Germany

Irreversible electroporation is an ablation method, which can be used to treat tumors in organs such as the liver or kidneys in a minimally invasive fashion, when performed under CT guidance. However, irreversible electroporation requires an adequate distribution of electric fields to be achieved during treatment to ensure treatment success. In order to validate the numerical models, it is useful to evaluate well-documented historical cases. The Department for Interventional radiology of the University clinic Leipzig, has performed several IRE therapies of tumors in livers with CT guidance. This allowed us to very accurately reproduce both the patient anatomy and electrode positions during treatment. Coupled with measured current and voltage data logged during pulse delivery, this allowed us to validate a model with coupled electric fields and joule heating. With heating taken into account, the computed currents matched very well with measured currents. The improved models will allow a more precise modelling of heating and heat-related effects during irreversible electroporation and also improve the prediction of ablation regions due occurring achievable with given treatment parameters. The STSM to Leipzig was a great success and a very pleasurable experience of working with motivated and highly skilled scientists.

Publication(s) originating from this mission

Journal Radiology and Oncology
Impact Factor (according to ISI Thomson) 1,912
Authors Kos B, Voigt P, Miklavcic D, Moche M
Title Careful treatment planning enables safe ablation of liver tumors adjacent to major blood vessels by percutaneous irreversible electroporation (IRE)
Year 2015
Issue 49
Pages 234-241
Status Published

 


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