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Dielectric properties of normal vs. cancerous liver tissue

STSM by Azadeh Peyman, Researcher

Period of mission: from 24/03/2014 to 28/03/2014

Home institution: Public Health England, Didcot, UK

Host institution: University of Ljubljana, Ljubljana, Slovenia

Scientific collaboration was carried out between Physical Dosimetry Department of Public Health England and Faculty of Electrical Engineering University of Ljubljana and Institute of Oncology Ljubljana. The aim of this mission was to characterize the dielectric properties of cancerous human liver tissues. The variation in dielectric properties of tissues as a result of pathological and physiological changes is an area of great interest in particular in distinguishing the differences between normal and diseased tissues. It increases our understanding of how electromagnetic fields interact with tissues of different pathological state. Dielectric measurements were carried out at 50MHz-10GHz on freshly excised liver tumour tissues using an open ended coaxial probe and a vector network analyser. Tumour samples were collected from 6 patients undergoing open surgery to mainly remove metastasis of adenocarcinoma which had spread to liver. The measured data is mapped according to the relevant histological and pathological information. It will provide vital information to enhance understanding of interaction between electric fields and cancerous tissues in particular for electroporation applications (enhanced drug delivery). The dielectric data collected in this experiment covers the microwave frequencies of the electromagnetic field spectrum which is quite useful in understanding the mechanisms involved in electroporation of tissues using nanosecond pulses. It is aimed to extend the measurements to frequencies below 1 MHz, where the majority of electroporation applications (millisecond pulses) are carried out.

Publication(s) originating from this mission

Journal Bioelectromagnetics
Impact Factor (according to ISI Thomson) 1,705
Authors Azadeh Peyman, Bor Kos, Mihajlo Djokić, Blaž Trotovšek, Clara Limbaeck-Stokin, Gregor Serša and Damijan Miklavčič
Title Variation in dielectric properties due to pathological changes in human liver 
Year 2015
Issue 36/8

Pages

603-612
Status Published

Oral presentation(s) originating from this mission

Event BioEM 2015
Location Asilomar Conference Center/California/USA
Period 14/06 - 19/06/2015
Authors Azadeh Peyman
Title Dielectric properties of human liver and liver tumours

 


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