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25/10/2012 (Added to site)
Author(s): Kis, E.; Baltas, E.; Kinyo, A.; Varga, E.; Nagy, N.; Gyulai, R.; Kemeny, L.; Olah, J.

Successful Treatment of Multiple Basaliomas with Bleomycinbased Electrochemotherapy: A Case Series of Three Patients with Gorlin-Goltz Syndrome

Journal: Acta Dermato-Venereologica, 92 (2012), pp. 1-4
DOI: 10.2340/00015555-1361
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Abstract: Gorlin-Goltz syndrome is a rare multisystemic disease, characterized by numerous basal cell carcinomas. The ideal approach for patients with the syndrome would be a treatment with a high cure rate, minimal scarring, short healing time and mild side-effects. Electrochemotherapy is a novel therapeutic option that ablates tumours with electrical current and simultaneously administered anticancer drugs. Three patients with Gorlin-Goltz syndrome were treated with electrochemotherapy using intravenous bleomycin. Clinical response was obtained in 98 (99%) of the lesions, 86 (87%) of them showed complete response. In 2 tumours, regression was confirmed with histological examination. Long-term cosmetic results were excellent. We consider electrochemotherapy to be an additional tool in the therapeutic armamentarium for Gorlin-Goltz syndrome, and suggest using it as early as possible in selected patients to avoid disfiguring scarring.


Keywords: bleomycin    electrochemotherapy   

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