print small

Participating Countries:

Algeria

Argentina

Australia

Austria

Belgium

Bosnia and Herzegovina

Bulgaria

Croatia

Czech Republic

Denmark

Finland

France

FYR of Macedonia

Germany

Greece

Iceland

Ireland

Israel

Italy

Lithuania

Morocco

Netherlands

New Zealand

Poland

Portugal

Romania

Russian Federation

Serbia

Slovenia

Spain

Sweden

Switzerland

Turkey

Ukraine

United Kingdom

United States

Member area provided by LTFE
COST is supported by the EU Framework Programme Horizon 2020
This website is supported by COST
28/08/2014 (Added to site)
Author(s): van Driel, V. J.; Neven, K. G.; van Wessel, H.; du Pre, B. C.; Vink, A.; Doevendans, P. A.; Wittkampf, F. H.

Pulmonary vein stenosis after catheter ablation: electroporation versus radiofrequency

Journal: Circulation: Arrhythmia and Electrophysiology, 7/4 (2014), pp. 734-738
DOI: 10.1161/​CIRCEP.113.001111
Request reprint  |  Tell your friend  | 

<p>&lt;p&gt;&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Abstract:&amp;lt;/strong&amp;gt;&amp;lt;br /&amp;gt; &amp;lt;br /&amp;gt; &amp;lt;strong&amp;gt;Background&amp;lt;/strong&amp;gt; Radiofrequency ablation inside pulmonary vein (PV) ostia can cause PV stenosis. A novel alternative method of ablation is irreversible electroporation, but the long-term response of PVs to electroporation ablation is unknown.&amp;lt;br /&amp;gt; &amp;lt;br /&amp;gt; &amp;lt;strong&amp;gt;Methods and Results&amp;lt;/strong&amp;gt; In ten 6-month-old pigs (60&amp;amp;ndash;75 kg), the response of PVs to circular electroporation and radiofrequency ablation was compared. Ten consecutive, nonarcing, electroporation applications of 200 J were delivered 5 to 10 mm inside 1 of the 2 main PVs, using a custom-deflectable, 18-mm circular decapolar catheter. Inside the other PV, circular radiofrequency ablation was performed using 30 W radiofrequency applications via an irrigated 4-mm ablation catheter. PV angiograms were made before ablation, immediately after ablation, and after 3-month survival. PV diameters and heart size were measured. With electroporation ablation, PV ostial diameter decreased 11&amp;amp;plusmn;10% directly after ablation, but had increased 19&amp;amp;plusmn;11% after 3 months. With radiofrequency ablation, PV ostial diameter decreased 23&amp;amp;plusmn;15% directly after ablation and remained 7&amp;amp;plusmn;17% smaller after 3 months compared with preablation diameter despite a 21&amp;amp;plusmn;7% increase in heart size during aging from 6 to 9 months.&amp;lt;br /&amp;gt; &amp;lt;br /&amp;gt; &amp;lt;strong&amp;gt;Conclusions&amp;lt;/strong&amp;gt; In this porcine model, multiple circumferential 200-J electroporation applications inside the PV ostia do not affect PV diameter at 3-month follow-up. Radiofrequency ablation inside PV ostia causes considerable PV stenosis directly after ablation, which persists after 3 months.&amp;lt;/p&amp;gt;&lt;/p&gt;</p>



Project Office

Working groups

Steering Committee

Founding members

DC Rapporteurs

Related sites: