print small

Participating Countries:

Algeria

Argentina

Australia

Austria

Belgium

Bosnia and Herzegovina

Bulgaria

Croatia

Czech Republic

Denmark

Finland

France

FYR of Macedonia

Germany

Greece

Iceland

Ireland

Israel

Italy

Lithuania

Morocco

Netherlands

New Zealand

Poland

Portugal

Romania

Russian Federation

Serbia

Slovenia

Spain

Sweden

Switzerland

Turkey

Ukraine

United Kingdom

United States

Member area provided by LTFE
COST is supported by the EU Framework Programme Horizon 2020
This website is supported by COST
20/05/2013 (Added to site)
Author(s): Yao, C. G.; Guo, F.; Li, C. X.; Sun, C. X.

Gene Transfer and Drug Delivery with Electric Pulse Generators

Journal: Current Drug Metabolism, 14/3 (2013), pp. 319-323
DOI: 10.2174/1389200211314030007
Request reprint  |  Tell your friend  | 

Abstract: Electroporation is a process that involves a series of intense electric pulses used to overcome the barrier of the cell membrane. The application of an external electric field may result in reversible breakdown of cell membrane. This transient state helps to introduce cells with a variety of different molecules, such as DNA and drug molecules, and is known as the fundamental mechanisms of gene transfer and drug delivery with electric pulses. This paper reviews (1) the utility of electric pulse generators in gene transfer and drug delivery, (2) development of electric pulse generators for utilizing them in gene transfer and drug delivery, (3) study of parameters of electric pulses used in gene transfer and drug delivery, (4) study of electrode configurations used in gene transfer and drug delivery.



Project Office

Working groups

Steering Committee

Founding members

DC Rapporteurs

Related sites: