print small

Participating Countries:

Algeria

Argentina

Australia

Austria

Belgium

Bosnia and Herzegovina

Bulgaria

Croatia

Czech Republic

Denmark

Finland

France

FYR of Macedonia

Germany

Greece

Iceland

Ireland

Israel

Italy

Lithuania

Morocco

Netherlands

New Zealand

Poland

Portugal

Romania

Russian Federation

Serbia

Slovenia

Spain

Sweden

Switzerland

Turkey

Ukraine

United Kingdom

United States

Member area provided by LTFE
COST is supported by the EU Framework Programme Horizon 2020
This website is supported by COST
04/07/2014 (Added to site)
Author(s): Sridhara, V.; Joshi, R. P.

Evaluations of a mechanistic hypothesis for the influence of extracellular ions on electroporation due to high-intensity, nanosecond pulsing

Journal: Biochimica et Biophysica Acta - Biomembranes, 1838/7 (2014), pp. 1793-1800
DOI: 10.1016/j.bbamem.2014.03.010
Request reprint  |  Tell your friend  | 

Abstract: The effect of ions present in the extracellular medium on electroporation by high-intensity, short-duration pulsing is studied through molecular dynamic simulations. Our simulation results indicate that mobile ions in the medium might play a role in creating stronger local electric fields across membranes that then reinforce and strengthen electroporation. Much faster pore formation is predicted in higher conductivity media. However, the impact of extracellular conductivity on cellular inflows, which depend on transport processes such as electrophoresis, could be different as discussed here. Our simulation results also show that interactions between cations (Na(+) in this case) and the carbonyl oxygen of the lipid headgroups could impede pore resealing.


Keywords: electric pulse    ionic transport    lipids    molecular dynamics    nanopore   

Project Office

Working groups

Steering Committee

Founding members

DC Rapporteurs

Related sites: