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25/04/2014 (Added to site)
Author(s): G. Saulis

Electrochemical Processes Occuring During Cell Electromanipulation Procedures

Book: Spugnini, E. P.; Baldi, A. (Eds.), Electroporation in Laboratory and Clinical Investigations. Nova Science Publishers, Inc., Hauppauge, NY, pp. 99–113
DOI: (ISBN: 978-1-61668-327-6)
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Abstract: During cell electromanipulation procedures, a cell suspension is exposed to a high-voltage electric pulse and a strong electric current passes through the solution. At each electrode-solution interface, electrochemical reactions occur that transfer electrons either to or from the electrode. In this chapter, theoretical background of the electrochemical processes taking place during cell electroporation procedures has been provided. These may include the evolution of gas, the separation of substances, the dissolution of the electrode or the appearance of new substances in the solution. The processes of electrolysis lead to the changes of the temperature, pH, and the chemical composition of the experimental medium.
The consequences of these electrochemical processes, both primary and secondary ones, which may be important for optimization of cell electromanipulation procedures, have been discussed. When using high-voltage electrical pulses for electroporation of cells and tissues, scientists must keep in mind that the products generated due to electrochemical reactions can influence the biochemical processes taking part in their experimental systems.


Keywords: electroporation   

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