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05/10/2015 (Added to site)
Author(s): Kostadinova, A.; Nikolova, B.; Handjiyska, P.; Berger, MR.; Tsoneva, I.

Combined effect of electroporation and miltefosine on keratinocyte cell line HaCaT

Journal: Romanian Reports in Physics, 67/3 (2015), pp. 995-1003
DOI: n/a
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Abstract: In this study we investigated the effect of combined treatment of HaCaT keratinocyte cells with electrical pulses (200–500V/cm) and the alkylphosholipid (ALP) miltefosine. The data show that electroporation in combination with miltefosine induces cytoskeleton disruption and increases the permeability of cell monolayers due to interruption of cell-cell junctions’, as documented by fluorescent imaging of ZO-1 and actin integrity. This was accompanied with reduction of cell viability. The combination of these conditions could be considered as a method for treating several types of skin cancer or other pathological conditions affecting the skin integrity.



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